Stereoselective Synthesis of β-Glycinamide Ribonucleotide.
Lisa NguDebarpita RaySamantha S WatsonPenny J BeuningMary Jo OndrechenGeorge Augustine O'DohertyPublished in: Molecules (Basel, Switzerland) (2022)
A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.
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