The body composition profile is associated with response to anti-TNF therapy in Crohn's disease and may offer an alternative dosing paradigm.

Nik Sheng Ding George MalietzisP F C LungL PenezW M YipS GabeJ T JenkinsA Hart

Published in: Alimentary pharmacology & therapeutics (2017)

In this cohort study, body composition profiles did not correlate well with BMI. Myopenia was associated with primary nonresponse with potential implications for dosing and serves as an explanation for pharmacokinetic failure.

Keyphrases

body composition
resistance training
bone mineral density
rheumatoid arthritis
body mass index
stem cells
human health
risk assessment
bone marrow
cell therapy
postmenopausal women