Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature.
Matthew HeltonMuhammad Abu-RmailehKevin ThomasMurat GokdenAlissa KanaanAnaliz RodriguezPublished in: Case reports in oncological medicine (2020)
From our literature review, most metastatic lesions in these composite tumors originated from neoplasms of the lung and kidney. Approximately 63% patients presented with ophthalmoplegia as the initial symptom while 23% displayed hormonal abnormalities. Postoperative mortality had a median of 3.5 months. In our patient, the presence of VHL and Notch2 mutations in both tumors highlights the possibility of using next-generation sequencing to help identify therapeutic targets even in complex composite neoplasms.
Keyphrases
- end stage renal disease
- squamous cell carcinoma
- small cell lung cancer
- case report
- copy number
- ejection fraction
- newly diagnosed
- chronic kidney disease
- patients undergoing
- peritoneal dialysis
- prognostic factors
- cell proliferation
- circulating tumor
- risk factors
- type diabetes
- patient reported outcomes
- dna methylation
- skeletal muscle
- adipose tissue
- insulin resistance
- growth hormone