Methylprednisolone acetate mitigates IL1β induced changes in matrix metalloproteinase gene expression in skeletally immature ovine explant knee tissues.

Kristen I BartonMay ChungCyril B FrankNigel G ShriveDavid A Hart

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

Methylprednisolone significantly mitigated IL1β induced mRNA expression for MMPs in the immature cartilage, synovium, and IPFP, but the extent of the responsiveness was tissue-, location-, and gene-specific.

Keyphrases

gene expression
high dose
dna methylation
total knee arthroplasty
high glucose
diabetic rats
genome wide
copy number
knee osteoarthritis
endothelial cells
transcription factor