Anemia induces gut inflammation and injury in an animal model of preterm infants.

Connie M ArthurDemet NalbantHenry A FeldmanBejan J SaeediJason MatthewsBrian S RobinsonNourine A KamiliAshley BennettGretchen A CressMartha Sola-VisnerRheinallt M JonesM Bridget ZimmermanAndrew S NeishRavi Mangal PatelPeggy NopoulosMichael K GeorgieffJohn D RobackJohn A WidnessCassandra D JosephsonSean R Stowell

Published in: Transfusion (2019)

Taken together, these results suggest that anemia can increase intestinal inflammation and barrier disruption likely through altered macrophage function, leading to the type of predisposing intestinal injury that may increase the risk for NEC.

Keyphrases

preterm infants
oxidative stress
chronic kidney disease
iron deficiency
low birth weight