Reactive sulfur species and their significance in health and disease.
Małgorzata IciekAnna Bilska-WilkoszMichał KozdrowickiMagdalena GórnyPublished in: Bioscience reports (2022)
Reactive sulfur species (RSS) have been recognized in the last two decades as very important molecules in redox regulation. They are involved in metabolic processes and, in this way, they are responsible for maintenance of health. This review summarizes current information about the essential biological RSS, including H2S, low molecular weight persulfides, protein persulfides as well as organic and inorganic polysulfides, their synthesis, catabolism and chemical reactivity. Moreover, the role of RSS disturbances in various pathologies including vascular diseases, chronic kidney diseases, diabetes mellitus Type 2, neurological diseases, obesity, chronic obstructive pulmonary disease and in the most current problem of COVID-19 is presented. The significance of RSS in aging is also mentioned. Finally, the possibilities of using the precursors of various forms of RSS for therapeutic purposes are discussed.
Keyphrases
- chronic obstructive pulmonary disease
- public health
- healthcare
- health information
- mental health
- sars cov
- coronavirus disease
- metabolic syndrome
- type diabetes
- insulin resistance
- weight loss
- health promotion
- lung function
- water soluble
- body mass index
- cystic fibrosis
- social media
- glycemic control
- small molecule
- genetic diversity
- brain injury
- blood brain barrier
- climate change
- binding protein