Antiparasitic Effect of Stilbene and Terphenyl Compounds against Trypanosoma cruzi Parasites.

Federica Bruno Germano CastelliFabrizio VitaleSimone CatanzaroValeria Vitale BadacoMarinella RobertiClaudia ColombaAntonio CascioManlio Tolomeo

Published in: Pharmaceuticals (Basel, Switzerland) (2021)

The antiparasitic activity of ST18 together with its ability to activate caspase-1 in infected macrophages and its low toxicity toward normal cells makes this compound interesting for further clinical investigation.

Keyphrases

induced apoptosis
trypanosoma cruzi
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation