Hypoxic lung adenocarcinoma-derived exosomal miR-1290 induces M2 macrophage polarization by targeting SOCS3.

Jiahui GuShengrui YangXueying WangYining WuJia WeiJian Xu

Published in: Cancer medicine (2023)

Hypoxic LUAD cells generate miR-1290-rich exosomes that promote M2 polarization of macrophages. Targeting exosomal miR-1290 may provide a potential immunotherapeutic strategy for LUAD.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
stem cells
induced apoptosis
cell cycle arrest
mesenchymal stem cells
drug delivery
pi k akt
risk assessment