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Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy.

Michael F HammerCollin T KrzyzaniakErfan BahramnejadKiran J SmelserJoshua B HackJoseph C WatkinsPatrick T Ronaldson
Published in: Clinical science (London, England : 1979) (2024)
The results underscore the central role of oxidative stress and BBB permeability in the early stages of epileptogenesis, as well as sex dimorphism in response to increasing neuronal hyperexcitability. Our results also highlight the need to include both sexes in preclinical studies to effectively translate results of drug efficacy studies.
Keyphrases
  • mouse model
  • oxidative stress
  • case control
  • blood brain barrier
  • dna damage
  • endothelial cells
  • young adults
  • adverse drug
  • mesenchymal stem cells
  • signaling pathway
  • diabetic rats
  • bone marrow
  • electronic health record