Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences.
Ludmiła SzewczakKatarzyna Donskow-ŁysoniewskaPublished in: Biomedicines (2020)
Autoimmune diseases are increasingly recognized as disease entities in which dysregulated cytokines contribute to tissue-specific inflammation. In organ-specific and multiorgan autoimmune diseases, the cytokine profiles show some similarities. Despite these similarities, the cytokines have different roles in the pathogenesis of different diseases. Altered levels or action of cytokines can result from changes in cell signaling. This article describes alterations in the JAK-STAT, TGF-β and NF-κB signaling pathways, which are involved in the pathogenesis of multiple sclerosis and systemic lupus erythematosus. There is a special focus on T cells in preclinical models and in patients afflicted with these chronic inflammatory diseases.
Keyphrases
- systemic lupus erythematosus
- multiple sclerosis
- signaling pathway
- oxidative stress
- end stage renal disease
- ejection fraction
- cell therapy
- newly diagnosed
- pi k akt
- single cell
- peritoneal dialysis
- transforming growth factor
- rheumatoid arthritis
- epithelial mesenchymal transition
- lps induced
- immune response
- nuclear factor
- patient reported
- endoplasmic reticulum stress