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Acute and sustained increase in endothelial biomarkers in COVID-19.

Raul MendezPaula González-JiménezAna LatorreMónica PiquerasLeyre BouzasKatheryn YépezAna FerrandoEnrique Zaldívar-OlmedaAntonio MoscardóRicardo AlonsoSoledad ReyesRosario Menéndez
Published in: Thorax (2021)
Endothelial injury is related to poor outcomes in respiratory infections yet little is known in relation to COVID-19. Performing a longitudinal analysis (on emergency department admission and post-hospitalisation follow-up), we evaluated endothelial damage via surrogate systemic endothelial biomarkers, that is, proadrenomedullin (proADM) and proendothelin, in patients with COVID-19. Higher proADM and/or proendothelin levels at baseline were associated with the most severe episodes and intensive care unit admission when compared with ward-admitted individuals and outpatients. Elevated levels of proADM or proendothelin at day 1 were associated with in-hospital mortality. High levels maintained after discharge were associated with reduced diffusing capacity.
Keyphrases
  • emergency department
  • endothelial cells
  • intensive care unit
  • coronavirus disease
  • sars cov
  • drug induced
  • liver failure
  • metabolic syndrome
  • early onset
  • adipose tissue
  • respiratory failure
  • skeletal muscle