Downregulation of epithelial sodium channel (ENaC) activity in human airway epithelia after low temperature incubation.

Sangya YadavCiaran A ShaughnessyPamela L ZeitlinPreston E Bratcher

Published in: BMJ open respiratory research (2021)

Significant transcriptional downregulation of ENaC subunits β and γ were observed, which may partially explain the decreased ENaC activity. We speculate that low temperature incubation may be a useful experimental paradigm to reduce ENaC activity in in vitro epithelial cultures.

Keyphrases

endothelial cells
cell proliferation
signaling pathway
transcription factor
induced pluripotent stem cells