CDK4/6 Inhibition Enhances the Efficacy of Standard Chemotherapy Treatment in Malignant Pleural Mesothelioma Cells.

Rita TerenzianiMaricla Galetti Silvia La Monica Claudia Fumarola Silvia Zoppi Roberta AlfieriGraziana DigiacomoAndrea Cavazzoni Delia Cavallo Massimo Corradi Marcello TiseoPier Giorgio PetroniniMara Bonelli

Published in: Cancers (2022)

Our results demonstrated the therapeutic potential of CDK4/6 inhibitors in combination with chemotherapy for the treatment of MPM and are consistent with the recent positive results in the MiST2 arm in abemaciclib-treated patients.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
induced apoptosis
squamous cell carcinoma
radiation therapy
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
smoking cessation
replacement therapy