Association of Early Seizure Prophylaxis With Posttraumatic Seizures and Mortality: A Meta-analysis With Evidence Quality Assessment.
Lilian Maria Godeiro CoelhoDeborah BlackerJohn HsuJoseph P NewhouseMichael Brandon WestoverSahar F ZafarLidia M V R MouraPublished in: Neurology. Clinical practice (2023)
Our data suggest that the evidence showing no association between early ASM use and 18- or 24-month epilepsy risk in adults with new-onset TBI was of low quality. The analysis indicated a moderate quality for the evidence showing no effect on all-cause mortality. Therefore, higher-quality evidence is needed as a supplement for stronger recommendations.