Androgen Receptor Splice Variants Contribute to the Upregulation of DNA Repair in Prostate Cancer.
Yuri TolkachAnika KremerGábor LotzMatthias SchmidThomas MayrSarah FörsterStephan GarbeSana HosniMarcus V CronauerIldikó KocsmárÉva KocsmárPéter RieszAbdullah AlajatiManuel RitterJoerg EllingerCarsten-Henning OhlmannGlen KristiansenPublished in: Cancers (2022)
The expression of AR splice variants such as AR-V7 in PCA patients following ADT might be a reason for reduced or absent therapy effects in patients on additional PARP inhibition due to the modulation of DNA repair gene expression. Consequently, AR-Vs should be further studied as predictive biomarkers for therapy response in this setting.