Distinct effects of SSRIs and SNRIs on Soluble Biomarkers in Blood and Cerebrospinal Fluid of people with HIV.

Mattia TrunfioBin TangJennifer E IudicelloQing MaDonald R FranklinDebra CooksonPatricia K RiggsMariana ChernerDavid J MooreRobert K HeatonScott L LetendreRonald J Ellis

Published in: The Journal of infectious diseases (2023)

SSRIs and SNRIs had distinct biomarker signatures. SSRIs were associated with reduced neurodegeneration, immune activation and oxidative stress in CSF, suggesting a role of SSRIs as adjunctive therapy in PWH.

Keyphrases

cerebrospinal fluid
oxidative stress
antiretroviral therapy
hiv infected
hiv positive
human immunodeficiency virus
hepatitis c virus
hiv testing
dna damage
genome wide
gene expression
men who have sex with men
dna methylation
signaling pathway
bone marrow
south africa
cell therapy