Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Yuan ZhuangHaifeng C XuPrashant V ShindeJens WarfsmannJelena VasilevskaBalamurugan SundaramKristina BehnkeJun HuangJessica I HoellArndt BorkhardtKlaus PfefferMohamed S TahaDiran HerebianErtan MayatepekDirk BrennerMohammad Reza AhmadianVerena KeitelDagmar WieczorekDieter HäussingerAleksandra A PandyraKarl S LangPhilipp A Lang

Published in: Gut (2019)

We show that FMRP plays a central role in the inhibition of TNF-mediated cell death during infection and liver disease.

Keyphrases

cell death
liver injury
drug induced
cell cycle arrest
rheumatoid arthritis
protein protein
small molecule
signaling pathway