Calcium-sensing receptor (CaSR) modulates vacuolar H+-ATPase activity in a cell model of proximal tubule.

Priscilla Marys Costa Dos SantosDeividi AmaralAna Lucia TararthuchRicardo Fernandez

Published in: Clinical and experimental nephrology (2018)

CaSR stimulation induces an increase in the vacuolar H+-ATPase activity of OKP cells, an effect that involves an increase in [Ca2+]i and require phospholipase C activity. The consequent decrease in intratubular pH could lead to increase ionization of luminal calcium, potentially enhancing its reabsorption in distal tubule segments and reducing the formation of calcium phosphate stones.

Keyphrases

stem cells
minimally invasive
oxidative stress
high resolution
cell proliferation
endoplasmic reticulum
protein kinase
simultaneous determination