Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction.

Khoa NguyenVinh Q ChauAdolfo G MauroDavid DurrantStefano ToldoAntonio AbbateAnindita DasFadi N Salloum

Published in: Journal of cardiovascular pharmacology and therapeutics (2020)

Na2S treatment after MI preserves LV function and improves survival through attenuation of inflammasome-mediated adverse remodeling. We propose H2S donors as promising therapeutic tools for ischemic HFrEF.

Keyphrases

heart failure
mouse model
left ventricular
ischemia reperfusion injury
signaling pathway
cerebral ischemia
atrial fibrillation
cardiac resynchronization therapy
stem cells
acute heart failure
brain injury
blood brain barrier
subarachnoid hemorrhage
free survival
cell therapy