Risk factors for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a three-centric case-control study.
Tiziana FeolaGiulia PulianiFranz SestiRoberta ModicaR CentelloR MinottaG CannavaleS Di MeglioV Di VitoR LaurettaMarialuisa AppetecchiaAnnamaria ColaoAndrea LenziAndrea M IsidoriAntongiulio FaggianoElisa GiannettaPublished in: Journal of endocrinological investigation (2022)
This study reinforces a role for family history of non-neuroendocrine GEP cancer, T2DM and obesity as independent risk factors for GEP-NENs and suggests a role of metformin as a protective factor in T2DM subjects. If confirmed, these findings could have a significant impact on prevention strategies for GEP-NENs.