Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control.

Wagner S DantasElizabeth R M ZunicaElizabeth C HeintzBolormaa VandanmagsarZ Elizabeth FloydYongmei YuHisashi FujiokaCharles L HoppelKathryn P BelmontChristopher L AxelrodJohn P Kirwan

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Mitochondrial uncoupling by agents such as BAM15 may mitigate age-related decline in muscle mass and function by molecular and cellular bioenergetic adaptations that confer protection against sarcopenic obesity.

Keyphrases

insulin resistance
quality control
skeletal muscle
metabolic syndrome
weight loss
oxidative stress
high fat diet induced
type diabetes
weight gain
nitric oxide synthase
adipose tissue
high intensity
nitric oxide
physical activity