Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer.
Maarten NeerincxDennis PoelDaoud L S SieNicole C T van GriekenRam C ShankaraiahFloor S W van der Wolf-de LijsterJan-Hein T M van WaesbergheJan-Dirk BurggraafPaul P EijkCornelis VerhoefBauke YlstraGerrit A MeijerMark A van de WielTineke E BuffartHenk M W VerheulPublished in: PloS one (2018)
A six miR expression signature was identified that predicted treatment response to fluoropyrimidine containing first line systemic treatment in patients with mCRC when combined with four clinicopathological factors. Independent validation demonstrated added predictive value of this miR-signature for predicting treatment response versus SD. However, added predicted value for separating patients with PD could not be validated. The clinical relevance of the identified miRs for predicting treatment response has to be further explored.