Comparison of pharmacokinetics and the exposure-response relationship of dapagliflozin between adolescent/young adult and adult patients with type 1 diabetes mellitus.

David BusseWeifeng TangMarkus ScheererThomas DanneTorben BiesterViktor SokolovDavid BoultonJoanna Parkinson

Published in: British journal of clinical pharmacology (2019)

Dapagliflozin PK and ER relationship were similar in the 2 analysed studies after accounting for covariate effects. These results suggest that no dose adjustment is required for adolescent patients with T1DM.

Keyphrases

young adults
mental health
childhood cancer
type diabetes
adipose tissue
estrogen receptor
case control
metabolic syndrome
insulin resistance
weight loss
glycemic control