Impact of Signet-Ring Cell Histology in the Management of Patients with Non-Metastatic Gastric Cancer: Results from a Retrospective Multicenter Analysis Comparing FLOT Perioperative Chemotherapy vs. Surgery Followed by Adjuvant Chemotherapy.
Riccardo GiampieriMaria Giuditta BaleaniAlessandro BittoniFrancesca RastelliVincenzo CatalanoMichela Del PreteSilvia ChiorriniGiada PinterpeFrancesco GrazianoFrancesca Chiara GiorgiRenato BisonniRosarita SilvaPaolo AlessandroniLara MencariniRossana BerardiPublished in: Cancers (2023)
Signet-ring positivity was associated with shorter DFS and OS in patients who received perioperative treatment with FLOT compared with surgery followed by adjuvant therapy. These data suggest that for patients with signet-ring cell histology, FLOT perioperative treatment might not always be the best choice of treatment, and further research should be focused on this group of patients.
Keyphrases
- minimally invasive
- end stage renal disease
- cardiac surgery
- patients undergoing
- single cell
- small cell lung cancer
- chronic kidney disease
- newly diagnosed
- clinical trial
- radiation therapy
- stem cells
- cell therapy
- acute coronary syndrome
- peritoneal dialysis
- atrial fibrillation
- electronic health record
- smoking cessation
- deep learning