Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?
Tú Nguyen-DumontZhi L TeoFleur HammetAlexis RobergeMaryam MahmoodiHelen TsimiklisDaniel J ParkBernard J PopeAndrew LonieMiroslav K KapuscinskiKhalid Mahmoodnull nullDavid E GoldgarGraham G GilesIngrid WinshipJohn L HopperMelissa C SoutheyPublished in: BMC cancer (2018)
Our study suggests that RNASEL:p.Glu265* may be a genetic modifier of risk for early-onset breast cancer predisposition in carriers of high-risk mutations. Much larger case-case and case-control studies are warranted to test the association observed in this report.