Persistent Bacteriuria and Antibodies Recognizing Curli/eDNA Complexes From Escherichia coli Are Linked to Flares in Systemic Lupus Erythematosus.

Ryan J PachuckiChelsea CorradettiLynne KohlerJay GhadialiPaul M GalloLauren NicastroSarah A TursiStefania GallucciÇagla TükelRoberto Caricchio

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

These results suggest that UTIs and persistent bacteriuria are environmental triggers of lupus and its flares. Antibodies against curli/eDNA could serve as a sign of systemic exposure to bacterial products in SLE.

Keyphrases

systemic lupus erythematosus
escherichia coli
disease activity
urinary tract infection
rheumatoid arthritis
klebsiella pneumoniae
cystic fibrosis
biofilm formation
staphylococcus aureus
life cycle
drug induced
risk assessment