SARS-CoV-2 shedding and evolution in immunocompromised hosts during the Omicron period: a multicenter prospective analysis.

Zoe RaglowDiya SurieJames D ChappellYuwei ZhuEmily T MartinJennie H KwonAnne E FroschAmira MohamedJulie GilbertEmily E BendallAuden BahrNatasha HalasaH Keipp TalbotCarlos G GrijalvaAdrienne BaughmanKelsey N WomackCassandra JohnsonSydney A SwanEmilia KoumansMeredith L McMorrowJennifer L HarcourtLydia J AthertonAshley BurroughsNatalie J ThornburgWesley H SelfAdam S Lauring

Published in: medRxiv : the preprint server for health sciences (2023)

In this cohort, prolonged replication-competent Omicron SARS-CoV-2 infections were uncommon. Within-host evolutionary rates were similar across patients, but individuals with infections lasting >56 days accumulated spike mutations, which were distinct from those seen globally.

Keyphrases

sars cov
end stage renal disease
respiratory syndrome coronavirus
chronic kidney disease
ejection fraction
newly diagnosed
peritoneal dialysis
clinical trial
genome wide
patient reported outcomes
gene expression
mechanical ventilation