Paget's disease of the nipple in a Her2-positive breast cancer xenograft model.

Katherine Drews-ElgerAna Cristina Sandoval-LeonAyse Burcu ErgonulAnna M JeggCarmen Gomez-FernandezPhilip C MillerDorraya El-AshryMarc E Lippman

Published in: Breast cancer research and treatment (2019)

Our results suggest that injection of HER2 + DT13 cells into the mammary fat pad of NSG mice recapitulates critical aspects of the pathophysiology of PD of the nipple, supporting the epidermotropic theory as the more likely to explain the histogenesis of this disease.

Keyphrases

positive breast cancer
induced apoptosis
adipose tissue
breast reconstruction
high fat diet induced
signaling pathway
metabolic syndrome
insulin resistance