Therapeutic Effects against Tissue Necrosis of Remote Ischemic Preconditioning Combined with Human Adipose-Derived Stem Cells in Random-Pattern Skin Flap Rat Models.

Changsik John PakSoo Young MoonYoung Eun LeeHyo Jin Kang

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2020)

The rIPC + hADSCs treatment appeared to reduce skin flap necrosis and activated neovascularization in rats. Therefore, it may be a good strategy for clinical treatment of ischemia-reperfusion injury.

Keyphrases

ischemia reperfusion injury
soft tissue
oxidative stress
endothelial cells
wound healing
cerebral ischemia
combination therapy
vascular endothelial growth factor
blood brain barrier
subarachnoid hemorrhage
breast reconstruction