Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice.
Takashi HaraHanae ToyamaYumi OhataTakeshi IkeuchiSumiko NakamuraToshio JohKen'ichi OhtsuboPublished in: Bioscience, biotechnology, and biochemistry (2022)
This study reports that black rice bran (BRB) intake for 50-52 consecutive weeks (∼12 months) reduces tau phosphorylation with a concomitant activation of insulin signaling and subsequent PI3K/AKT pathway in the brain of aged normal mice. BRB holds promise for preventing the formation of neurofibrillary tangles consisting of hyperphosphorylated tau, a pathological hallmark of Alzheimer's disease.
Keyphrases
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