F0F1 ATP synthase regulates extracellular calcium influx in human neutrophils by interacting with Cav2.3 and modulates neutrophil accumulation in the lipopolysaccharide-challenged lung.
Baoyi ZhuZhengfu FengYan GuoTian ZhangAi MaiZhanfang KangTing WeijenDai WangDazhong YinDongxing ZhuJun GaoPublished in: Cell communication and signaling : CCS (2020)
In this study, we identified a mechanism by which neutrophil activity is modulated, with simultaneous regulation of neutrophil-mediated pulmonary damage. These results show that surface F-ATPase of neutrophils is a potential innate immune therapeutic target.