Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels.
Aytuğ K KiperMauricio BedoyaSarah StalkeStefanie MarzianDavid RamírezAlicia de la CruzDiego A PerazaAlba Vera-ZambranoJosé C E Márquez MontesinosBárbara A Arévalo RamosSusanne RinnéTeresa GonzalezCarmen ValenzuelaWendy GonzalezNiels DecherPublished in: British journal of pharmacology (2021)
Local anaesthetics bind to the central cavity and the side pockets, which provide a crucial key to the molecular understanding of their Kv channel affinity and stereoselectivity, as well as their spectrum of side effects.