Dec2 attenuates autophagy in inflamed periodontal tissues.

Shunichi OkaXiaoyan LiFuyuki SatoFengzhu ZhangNitesh TewariChongchong ChenLiangjun ZhongMakoto MakishimaYi LiuUjjal Kumar Bhawal

Published in: Immunity, inflammation and disease (2020)

These results demonstrate that a Dec2 deficiency can alleviate LPS-induced inflammation via the ERK/mTOR signaling pathway by regulating autophagy, conceivably delivering a novel approach for the detection of periodontal treatments.

Keyphrases

signaling pathway
lps induced
pi k akt
inflammatory response
oxidative stress
induced apoptosis
epithelial mesenchymal transition
cell death
endoplasmic reticulum stress
cell proliferation
gene expression
label free
loop mediated isothermal amplification
real time pcr