Exploration of Berberine Against Ulcerative Colitis via TLR4/NF-κB/HIF-1α Pathway by Bioinformatics and Experimental Validation.
Jilei LiWenchao DanChenchen ZhangNian LiuYichong WangJixiang LiuShengsheng ZhangPublished in: Drug design, development and therapy (2024)
Through network pharmacology analysis and experimental substantiation, this study confirmed that berberine enhances UC treatment outcomes by inhibiting the TLR4/NF-κB/HIF-1α axis, thereby mitigating inflammatory reactions and improving colonic pathology.