Th2 and Th17-Associated Immunopathology Following SARS-CoV-2 Breakthrough Infection in Spike-Vaccinated ACE2-humanized Mice.
Tianyi ZhangNicholas MagazineMichael C McGeeMariano CarossinoGianluca VeggianiKonstantin G KousoulasAvery AugustWeishan HuangPublished in: bioRxiv : the preprint server for biology (2023)
This research investigates the safety and efficacy of a Spike protein subunit vaccine adjuvanted with Alum and CpG in an ACE2-humanized mouse model, simulating SARS-CoV-2 breakthrough infections. The study reveals that despite robust protection against severe COVID-19, vaccinated mice exhibit substantial pulmonary immunopathology, including eosinophilia and enhanced Th2 effector immunity, following breakthrough infections. Surprisingly, the study also uncovers a significant systemic Th17 inflammatory response in vaccinated mice. This research sheds light on the potential risks associated with COVID-19 vaccine breakthrough infections and the need for a comprehensive understanding of vaccine-induced immune responses, emphasizing the importance of ongoing research, surveillance, and careful vaccine development for both protection and safety in the fight against the COVID-19 pandemic.
Keyphrases
- sars cov
- inflammatory response
- immune response
- coronavirus disease
- respiratory syndrome coronavirus
- mouse model
- high fat diet induced
- public health
- dendritic cells
- dna methylation
- human health
- type diabetes
- risk assessment
- insulin resistance
- toll like receptor
- monoclonal antibody
- metabolic syndrome
- regulatory t cells
- amino acid
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