Combination of M2e peptide with stalk HA epitopes of influenza A virus enhances protective properties of recombinant vaccine.
Liudmila M TsybalovaLiudmila A StepanovaMarina A ShuklinaEugenia S MardanovaRoman Y KotlyarovMarina V PotapchukSergei A PetrovElena A BlokhinaNikolai V RavinPublished in: PloS one (2018)
This study demonstrates that the intranasal administration of Flg-HA2-2-4M2e recombinant protein induces a strong immune response which provides broad protection against various influenza viruses. This construct is therefore a strong candidate for development as a universal vaccine.