Design of Chitosan Nanocapsules with Compritol 888 ATO® for Imiquimod Transdermal Administration. Evaluation of Their Skin Absorption by Raman Microscopy.

María Javiera Alvarez-FigueroaDaniela Narváez-ArayaNicolás Armijo-EscalonaEduardo A Carrasco-FloresJosé Vicente González-Aramundiz

Published in: Pharmaceutical research (2020)

This study demonstrated the utility of Raman Microscopy to evaluate the drugs transdermal penetration of in the different layers of the skin. Graphical Abstract New imiquimod nanocapsules: evaluation of their skin absorption by Raman Microscopy and effect of the compritol 888ATO® in the imiquimod release profile.

Keyphrases

label free
wound healing
single molecule
high resolution
soft tissue
high speed
high throughput
optical coherence tomography
raman spectroscopy
drug delivery
mass spectrometry