Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects in adult outbred CFW mice.

Kristyn N BorrelliKelly K WingfieldEmily J YaoCatalina A ZamoranoKatherine D SenaJacob A BeierleMichelle A RoosHuiping ZhangElisha M WachmanCamron D Bryant

Published in: bioRxiv : the preprint server for biology (2023)

We replicated some NOWS model traits via 1x-daily morphine (P1-P14).We found a downregulation of myelination genes in nucleus accumbens on P15.There were no effects on learning/memory or reward sensitivity in adults.

Keyphrases

gene expression
genome wide
dna methylation
chronic pain
pain management
cell proliferation
signaling pathway
physical activity
working memory
high fat diet induced
white matter
bioinformatics analysis
metabolic syndrome
skeletal muscle
multiple sclerosis
adipose tissue
transcription factor
young adults