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New Cu +2 Complexes with N-Sulfonamide Ligands: Potential Antitumor, Antibacterial, and Antioxidant Agents.

Adriana Corina HanganAlexandru TurzaRoxana-Liana LucaciuBogdan SevastreEmőke PállLuminița Simona OpreanGheorghe Borodi
Published in: Molecules (Basel, Switzerland) (2022)
Nowadays, the discovery of a new non-toxic metal complex with biological activity represents a very active area of research. Two Cu +2 complexes, [Cu(L1) 2 (H 2 O) 3 ] (C1) (HL1= N-(5-(4-methylphenyl)-[1,3,4]-thiadiazole-2-yl)-naphtalenesulfonamide) and [Cu(L2) 2 (py) 2 (H 2 O)] (C2) (HL2= N-(5-ethyl-[1,3,4]-thiadiazole-2-yl)-naphtalenesulfonamide), with two new ligands were synthesized. The X-ray crystal structures of the complexes were determined. In both complexes, Cu +2 is five-coordinated, forming a CuN 2 O 3 and CuN 4 O chromophore, respectively. The ligands act as monodentate, coordinating the metal ion through a single N thiadiazole atom; for the C2 complex, the molecules from the reaction medium (pyridine and water) are also involved in the coordination of Cu +2 . The complexes have a distorted square pyramidal square-planar geometry. The compounds were characterized by FT-IR, electronic EPR spectroscopy, and magnetic methods. The nuclease activity studies confirm the complexes' capacity to cleave the DNA molecule. Using a xanthine-xanthine oxydase system, the SOD mimetic activity of the complexes was demonstrated. Cytotoxicity studies were carried out on two tumor cell lines (HeLa, WM35) and on a normal cell line (HFL1) using the MTT method, with cisplatin used as a positive control. The antibacterial activity of the complexes was investigated against two Gram-positive and two Gram-negative bacteria, and compared with Amoxicillin and Norfloxacin using the disk diffusion method. Both complexes showed in vitro biological activity but the C2 complex was more active. A lack of in vivo toxicity was demonstrated for the C2 complex by performing hepatic, renal, and hematological studies on Swiss mice.
Keyphrases
  • high resolution
  • oxidative stress
  • mass spectrometry
  • high throughput
  • signaling pathway
  • magnetic resonance imaging
  • case control
  • circulating tumor
  • high speed
  • dna binding
  • solid state