Catechol-O-Methyltransferase Genotype and Gait Speed Changes over 10 Years in Older Adults.

Andrea L RossoCaterina RosanoRobert BoudreauRobyn MassaKristine YaffeSuzanne SatterfieldTamara HarrisAndrea L Rosso

Published in: Journal of the American Geriatrics Society (2017)

These findings indicate a role of dopaminergic regulation of gait speed in community-dwelling older adults and of prefrontal cortex involvement in gait performance. Future work should investigate the molecular integrity of dopaminergic networks and gait changes over time and structural changes in the brain with COMT and gait decline in older adults.

Keyphrases

cerebral palsy
prefrontal cortex
physical activity
white matter
functional connectivity