Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones.

Alicia Monleón Gonzalo Blay José R Pedro

Published in: Molecules (Basel, Switzerland) (2022)

A convenient procedure of synthesis of N -carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.

Keyphrases

molecular docking
room temperature
minimally invasive
ionic liquid
capillary electrophoresis
crystal structure
electron transfer