Inverse Association of Age with Risk of Lymph Node Metastasis in Superficial Colorectal Cancer: A Large Population-Based Study.
Zhi-Zheng GeLong-Ci SunChao-Tao TangQian LiangYang-Yang ZhouHui-Min ChenYun-Jie GaoZhi-Zheng GePublished in: The oncologist (2020)
Endoscopic resection (ER) is widely used to resect differentiated superficial colorectal cancer (SCRC) without lymph node metastasis (LNM). However, no study has ever investigated risk of LNM of early-onset SCRC compared with average onset SCRC to explore whether ER is suitable for early-onset SCRC. To the authors' knowledge, this population-based study is the first study to find inverse correlation between age at diagnosis and risk of LNM in differentiated SCRCs. This finding indicates that ER may not be suitable for young patients with differentiated SCRC. Because the 30-day operative mortality after surgery is higher but the risk of LNM is lower in older patients compared with younger patients, ER for differentiated SCRCs may be advantageous over surgery for older patients.
Keyphrases
- early onset
- lymph node metastasis
- late onset
- squamous cell carcinoma
- papillary thyroid
- estrogen receptor
- endoplasmic reticulum
- breast cancer cells
- end stage renal disease
- healthcare
- ejection fraction
- prognostic factors
- coronary artery bypass
- percutaneous coronary intervention
- high resolution
- patient reported outcomes
- acute coronary syndrome
- single molecule