MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.

Xin ZhouJianzhu LuoHaixiang XieZhongliu WeiTianman LiJunqi LiuXiwen LiaoGuangzhi ZhuTao Peng

Published in: Cell death discovery (2022)

MCM2 is a good prognostic marker. MCM2 enhances the stemness of HCC cells by affecting the Hippo signaling pathway, while the downregulation of MCM2 inhibits resistance towards sorafenib.

Keyphrases

signaling pathway
induced apoptosis
epithelial mesenchymal transition
stem cells
pi k akt
cell cycle arrest
cell proliferation
cancer stem cells