Ischemic Mitral Regurgitation: A Multifaceted Syndrome with Evolving Therapies.
Mattia VinciguerraFrancesco GrigioniSilvia RomitiGiovanni BenfariDavid RoseCristiano SpadaccioSara CiminoAntonio De BellisErnesto GrecoPublished in: Biomedicines (2021)
Dysfunction of the left ventricle (LV) with impaired contractility following chronic ischemia or acute myocardial infarction (AMI) is the main cause of ischemic mitral regurgitation (IMR), leading to moderate and moderate-to-severe mitral regurgitation (MR). The site of AMI exerts a specific influence determining different patterns of adverse LV remodeling. In general, inferior-posterior AMI is more frequently associated with regional structural changes than the anterolateral one, which is associated with global adverse LV remodeling, ultimately leading to different phenotypes of IMR. In this narrative review, starting from the aforementioned categorization, we proceed to describe current knowledge regarding surgical approaches in the management of IMR.
Keyphrases
- acute myocardial infarction
- percutaneous coronary intervention
- high intensity
- left ventricular
- ischemia reperfusion injury
- healthcare
- cerebral ischemia
- oxidative stress
- mitral valve
- pulmonary hypertension
- early onset
- case report
- adverse drug
- magnetic resonance
- drug induced
- smooth muscle
- contrast enhanced
- coronary artery disease
- atrial fibrillation
- brain injury
- subarachnoid hemorrhage
- congenital heart disease
- computed tomography
- electronic health record