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Associations between gut microbiota characteristics and non-motor symptoms following pharmacological and surgical treatments in Parkinson's disease patients.

Agnieszka Gorecka-MazurAnna Krygowska-WajsAgata FurgalaJiaqi LiBenjamin MisselwitzWojciech PietraszkoBorys KwintaBahtiyar Yilmaz
Published in: Neurogastroenterology and motility (2024)
Advanced PD patients on medication exhibit more gastrointestinal issues, despite relatively stable microbial diversity, indicating a complex interaction between gut microbiota, PD progression, and treatment effects. An imbalanced gut-brain axis, particularly due to reduced butyrate production, may lead to constipation by affecting the enteric nervous system, which emphasizes the need to incorporate gut microbiome insights into treatment strategies.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • healthcare
  • prognostic factors
  • peritoneal dialysis
  • emergency department
  • microbial community
  • replacement therapy