Cyclobenzaprine Raises ROS Levels in Leishmania infantum and Reduces Parasite Burden in Infected Mice.
Edézio Ferreira Cunha-JúniorValter Viana Andrade-NetoMarta Lopes LimaThais Alves da Costa-SilvaAndres J Galisteo JuniorMaria A AbengózarCoral BarbasLuis RivasElmo Eduardo Almeida-AmaralAndre Gustavo TemponeEduardo Caio Torres-SantosPublished in: PLoS neglected tropical diseases (2017)
To the best of our knowledge, this study is the first report of the in vivo antileishmanial activity of the FDA-approved drug CBP. Modulation of immune response and induction of oxidative stress in parasite seem to contribute to this efficacy.