A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.
Kai ZhengHua WanJie ZhangGuangyu ShanNingning ChaiDongdong LiNan FangLina LiuJingbo ZhangRong DuQixi WuXichuan LiChunze ZhangPublished in: Journal of translational medicine (2020)
We established a new NGS-based MSI classifier, USCI-msi, with as few as 9 microsatellite loci for detecting MSI status in CRC cases. This approach possesses 100% sensitivity and specificity, and performed robustly in samples with low tumor purity.