Liquid biopsy for ALK-positive early non-small-cell lung cancer predicts disease relapse.
Ji LiWen DongLi Na LiuYi Jiang HuangMei Fang XiaoPublished in: Future oncology (London, England) (2020)
Background: We aimed to determine whether circulating tumor cells (CTCs) and cell-free DNA (cfDNA) aids in prognosis of relapse-free survival (RFS). Methods: Non-small cell lung cancer patients with ALK mutations were recruited prospectively. CTCs and cfDNA were quantified at different time points. RFS was estimated and correlated. Results: Baseline median CTCs and cfDNA were 16 cells and 57 ng/mL and declined to nine cells and 30 ng/mL, respectively, postsurgery in 150 patients. Interestingly, patients without detectable CTCs postsurgery fared better for RFS. cfDNA monitoring showed deviations within 7 months of surgery that were significant predictors for RFS. Conclusion: Short-term monitoring of CTCs and cfDNA variations shows promise for early risk detection and may aid in better disease control.
Keyphrases
- circulating tumor cells
- free survival
- end stage renal disease
- newly diagnosed
- circulating tumor
- peritoneal dialysis
- prognostic factors
- cell cycle arrest
- advanced non small cell lung cancer
- ionic liquid
- patient reported outcomes
- cell death
- deep learning
- artificial intelligence
- patient reported
- label free
- atrial fibrillation
- tyrosine kinase