Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.

Anne C Silva BarbosaDong ZhouYang XieYou-Jin ChoiHung-Chun TungXinyun ChenMeishu XuRobert B GibbsSamuel M PoloyacSilvia LiuYanping YuJianhua LuoYouhua LiuWen Xie

Published in: Journal of the American Society of Nephrology : JASN (2020)

SULT1E1 appears to have a novel function in the pathogenesis of AKI. Our findings suggest that inhibitors of SULT1E1 might have therapeutic utility in the clinical management of AKI.

Keyphrases

acute kidney injury
high fat diet induced
estrogen receptor
mouse model
ischemia reperfusion injury
type diabetes
oxidative stress
metabolic syndrome
skeletal muscle
insulin resistance
wild type