The essential role of O-GlcNAcylation in hepatic differentiation.

Dakota R Robarts Manasi Kotulkar Diego Paine CabreraKaitlyn K VennemanJohn A HanoverNatasha E ZacharaChad Slawson Udayan Apte

Published in: Hepatology communications (2023)

Our study shows that O-GlcNAcylation is a critical regulator of hepatic differentiation, and loss of O-GlcNAcylation promotes hepatocarcinogenesis. These data highlight increasing O-GlcNAcylation as a potential therapy in chronic liver diseases, including HCC.

Keyphrases

electronic health record
transcription factor
big data
climate change
mesenchymal stem cells
replacement therapy